I am a massive Distrobox fan. I do not use it for security though.
create environments for specific purposes: dev, testing, cybersecurity work, video, AI, etc
access to the full app library of any distro
isolation of multiple large apps for easy and complete removal when you are done with them
use Glibc apps on your MUSL distro
install apps easily on an immutable distro
total compatibility ( eg. Legally install a real RHEL9 Distrobox for free )
”try out” an unfamiliar distro without a VM
experiment and break things without messing up your main system
separate your distro base from your userland ( eg. Minimal Debian Stable install with pretty much all apps coming from an Arch Linux Distrobox ). Rock solid stability of the base system paired with a massive ecosystem of up-to-date packages.