What are some SNDRIs you're aware of?
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wrote on last edited by [email protected]
Serotonin-Norepinephrine-Dopamine Reuptake Inhibitors
- Cocaine
- Possibly venlafaxine (at higher doses, just learned of this)
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Serotonin-Norepinephrine-Dopamine Reuptake Inhibitors
- Cocaine
- Possibly venlafaxine (at higher doses, just learned of this)
Never heard of this before but wikipedia has a list.
https://en.wikipedia.org/wiki/Serotonin–norepinephrine–dopamine_reuptake_inhibitor
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Serotonin-Norepinephrine-Dopamine Reuptake Inhibitors
- Cocaine
- Possibly venlafaxine (at higher doses, just learned of this)
https://en.wikipedia.org/wiki/Tesofensine
It's under trials for obesity. It has a half-life of like seven days. I've seen it for sale online, but it was quite expensive.
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https://en.wikipedia.org/wiki/Tesofensine
It's under trials for obesity. It has a half-life of like seven days. I've seen it for sale online, but it was quite expensive.
Would it literally be dosed weekly az opposed to daily?
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Would it literally be dosed weekly az opposed to daily?
No I think the dose used in studies is like 0.5-1.0mg once a day.
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Serotonin-Norepinephrine-Dopamine Reuptake Inhibitors
- Cocaine
- Possibly venlafaxine (at higher doses, just learned of this)
wrote on last edited by [email protected]Bupropion is a NDRI. Then you would have to add on an SSRI. However, 2 antidepressants aren't usually prescribed together.
Edit: dextromethorphan/bupropion (brand name Auvelity). The dextromethorphan hits multiple targets including NMDA and sigma 1, but technically has some inhibition activity to SERT. I am unsure how strong that activity is, whether it is dose dependant, if its an active metabolite etc. Also should point out that nowhere on the manufacturers website do they talk about using the dextromethorphan to hit serotonin. According to the website, the true mechanism of action of Auvelity for treating MDD is not well understood.
Edit2: check out this page. Gives more info and some references. Apparently fairly strong against SERT. [(https://tmedweb.tulane.edu/pharmwiki/doku.php/dextromethorphan)]