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Bitch shape attack

Scheduled Pinned Locked Moved Lemmy Shitpost
lemmyshitpost
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  • G [email protected]

    Frankly, all life and life-adjacent things on this planet are either nanomachines or scalable nanomachines.

    P This user is from outside of this forum
    P This user is from outside of this forum
    [email protected]
    wrote on last edited by
    #15

    One might call those scaled up nanomachines "machines".

    G 1 Reply Last reply
    8
    • F [email protected]

      I vaguely remember something about organelles inside a cell used to be seperate entities too

      vindictivejudge@lemmy.worldV This user is from outside of this forum
      vindictivejudge@lemmy.worldV This user is from outside of this forum
      [email protected]
      wrote on last edited by
      #16

      Mitochondria, for sure. They even still have their own DNA separate from your actual human DNA.

      1 Reply Last reply
      8
      • B [email protected]
        This post did not contain any content.
        G This user is from outside of this forum
        G This user is from outside of this forum
        [email protected]
        wrote on last edited by
        #17

        I will forever choose to die on the hill that tumblr humor is not funny

        match@pawb.socialM 1 Reply Last reply
        3
        • P [email protected]

          One might call those scaled up nanomachines "machines".

          G This user is from outside of this forum
          G This user is from outside of this forum
          [email protected]
          wrote on last edited by
          #18

          Never heard of it. Did you mean to say gigananomachines?

          1 Reply Last reply
          11
          • G [email protected]

            In the same way that the mafia plays a crucial role in the Italian mafia government. They’re still a bunch of dicks, even if they’re working for us. Move ‘em 2 millimeters in the wrong direction and you’ll have a bad time

            Q This user is from outside of this forum
            Q This user is from outside of this forum
            [email protected]
            wrote on last edited by
            #19

            Move ‘em 2 millimeters in the wrong direction and you’ll have a bad time

            Are you referring to getting, I dunno, yogurt in places outside the digestive tract?

            My understanding was that gut bacteria play a pretty crucial (beneficial) role in overall health, not to mention the whole gut-brain stuff.

            G 1 Reply Last reply
            0
            • G [email protected]

              I will forever choose to die on the hill that tumblr humor is not funny

              match@pawb.socialM This user is from outside of this forum
              match@pawb.socialM This user is from outside of this forum
              [email protected]
              wrote on last edited by
              #20

              then die

              1 Reply Last reply
              5
              • Q [email protected]

                Move ‘em 2 millimeters in the wrong direction and you’ll have a bad time

                Are you referring to getting, I dunno, yogurt in places outside the digestive tract?

                My understanding was that gut bacteria play a pretty crucial (beneficial) role in overall health, not to mention the whole gut-brain stuff.

                G This user is from outside of this forum
                G This user is from outside of this forum
                [email protected]
                wrote on last edited by
                #21

                Take some of those same bacteria and set them directly against the intestinal lining without any of the delicious mucus in the way and you’ll have a slightly unpleasant time. And I’m being literal. It’ll be aggravating, and deleterious to your long term health, but usually not immediately life threatening. They’re absolutely beneficial, but they’re in it for themselves. They’re not beneficent, they just are, which was all the point I intended to make.

                1 Reply Last reply
                0
                • doom@ttrpg.networkD [email protected]

                  explain please

                  K This user is from outside of this forum
                  K This user is from outside of this forum
                  [email protected]
                  wrote on last edited by [email protected]
                  #22

                  Happily! Basically, the true placenta we mammals (Eutheria) have is what allows such a long gestation period. Unlike our closely related marsupials, that quickly deplete their resources and must give birth, our placenta allows for a continuous exchange of nutrients. This involves a quite complicated process of embryonic tissue invading the uterine wall, so you can imagine the kind of immunological regulation that must be taking place for that to work.

                  So you'd assume we have several genes highly specific to our placenta that appear when we Eutherians first appeared... right? No! Turns out the vast majority already existed in jawed vertebrates (our common ancestor with sharks), then quite a lot show up in bony fish (our common ancestor with most things you call fish), and just one shows up in Tetrapoda (our common ancestor with amphibians).

                  So most of the framework for developing an organ such as the placenta already existed for millions of years, so what exactly was missing before it could finally show up in evolutionary history? The two genes that are absolutely required for this whole crazy "let's invade the mother's uterine wall tissue but NOT trigger her immune system" part: CSF2 and a group of closely related genes called syncitins.

                  Syncitins are the star here, because they're actually a gene that came from ancient retroviruses. In the virus, they were expressed in the envelope and controlled the fusion between the viral particle and the host cell. These viruses got integrated into our genome, and this "fusion with the host cell" mechanism became extremely useful and crucial for the placenta, basically allowing it to exist.

                  gandalf_der_12te@discuss.tchncs.deG J 7 3 Replies Last reply
                  10
                  • K [email protected]

                    Happily! Basically, the true placenta we mammals (Eutheria) have is what allows such a long gestation period. Unlike our closely related marsupials, that quickly deplete their resources and must give birth, our placenta allows for a continuous exchange of nutrients. This involves a quite complicated process of embryonic tissue invading the uterine wall, so you can imagine the kind of immunological regulation that must be taking place for that to work.

                    So you'd assume we have several genes highly specific to our placenta that appear when we Eutherians first appeared... right? No! Turns out the vast majority already existed in jawed vertebrates (our common ancestor with sharks), then quite a lot show up in bony fish (our common ancestor with most things you call fish), and just one shows up in Tetrapoda (our common ancestor with amphibians).

                    So most of the framework for developing an organ such as the placenta already existed for millions of years, so what exactly was missing before it could finally show up in evolutionary history? The two genes that are absolutely required for this whole crazy "let's invade the mother's uterine wall tissue but NOT trigger her immune system" part: CSF2 and a group of closely related genes called syncitins.

                    Syncitins are the star here, because they're actually a gene that came from ancient retroviruses. In the virus, they were expressed in the envelope and controlled the fusion between the viral particle and the host cell. These viruses got integrated into our genome, and this "fusion with the host cell" mechanism became extremely useful and crucial for the placenta, basically allowing it to exist.

                    gandalf_der_12te@discuss.tchncs.deG This user is from outside of this forum
                    gandalf_der_12te@discuss.tchncs.deG This user is from outside of this forum
                    [email protected]
                    wrote on last edited by
                    #23

                    So, in other words, viruses did parts of the work of evolution by inventing the CSF2 and syncitin genes?

                    And that regulates the immune system to not respond to foreign tissue?

                    K 1 Reply Last reply
                    1
                    • F [email protected]

                      I vaguely remember something about organelles inside a cell used to be seperate entities too

                      gandalf_der_12te@discuss.tchncs.deG This user is from outside of this forum
                      gandalf_der_12te@discuss.tchncs.deG This user is from outside of this forum
                      [email protected]
                      wrote on last edited by
                      #24

                      Yeah but they didn't use to be viruses, they used to be bacteria.

                      And they didn't integrate into human genome. They're just another foreign body that lives inside human cells, but they have their own genome still.

                      1 Reply Last reply
                      2
                      • kolanaki@pawb.socialK [email protected]

                        Viruses are nanomachines.

                        Change my mind.

                        gandalf_der_12te@discuss.tchncs.deG This user is from outside of this forum
                        gandalf_der_12te@discuss.tchncs.deG This user is from outside of this forum
                        [email protected]
                        wrote on last edited by
                        #25

                        they're not so much machines and more blueprints that makes the machine that's already there do different stuff.

                        1 Reply Last reply
                        0
                        • G [email protected]

                          In the same way that the mafia plays a crucial role in the Italian mafia government. They’re still a bunch of dicks, even if they’re working for us. Move ‘em 2 millimeters in the wrong direction and you’ll have a bad time

                          gandalf_der_12te@discuss.tchncs.deG This user is from outside of this forum
                          gandalf_der_12te@discuss.tchncs.deG This user is from outside of this forum
                          [email protected]
                          wrote on last edited by
                          #26

                          I'm actually interested, is this true?

                          When bacteria were first discovered, people found them in the gut and thought "oh, that's horrible. bacteria cause diseases, so we must get rid of them." it was only found out much later that bacteria in the gut can improve health on average.

                          the same is true for many other categories of living beings, such as insects (worms), fungi; and now my question is whether it could be the same for viruses?

                          G 1 Reply Last reply
                          0
                          • T [email protected]

                            Who's going to tell them about prions?

                            R This user is from outside of this forum
                            R This user is from outside of this forum
                            [email protected]
                            wrote on last edited by [email protected]
                            #27

                            Fucking prions. When I first learned about them in high school they really made me freak out. They are like the new game+ final boss of things fucking with things. Like how can they even infect other things, fucking mangled and misfolded looking ass, fuck them!

                            D 1 Reply Last reply
                            5
                            • gandalf_der_12te@discuss.tchncs.deG [email protected]

                              I'm actually interested, is this true?

                              When bacteria were first discovered, people found them in the gut and thought "oh, that's horrible. bacteria cause diseases, so we must get rid of them." it was only found out much later that bacteria in the gut can improve health on average.

                              the same is true for many other categories of living beings, such as insects (worms), fungi; and now my question is whether it could be the same for viruses?

                              G This user is from outside of this forum
                              G This user is from outside of this forum
                              [email protected]
                              wrote on last edited by [email protected]
                              #28

                              Some perform tasks, but they largely just take up space, and that’s a good thing. Your body’s full of materials that malignantly pathogenic bacteria would love to get their hands on. Bacteria that are largely incapable of doing anything to us take up space that would otherwise be occupied. You’d likely prefer an old squatter living in your walls, rather than a crackhead. You’d probably choose an electrician, but that’s life. Better they’re largely benign than overtly and desperately malicious.

                              You factually do have a viral balance in your internal ecosystem. Bacteriophages cull populations, and some viruses hyper-specialize in attacking cancer. There are more examples, but I can’t immediately recall

                              gandalf_der_12te@discuss.tchncs.deG 1 Reply Last reply
                              1
                              • K [email protected]

                                Happily! Basically, the true placenta we mammals (Eutheria) have is what allows such a long gestation period. Unlike our closely related marsupials, that quickly deplete their resources and must give birth, our placenta allows for a continuous exchange of nutrients. This involves a quite complicated process of embryonic tissue invading the uterine wall, so you can imagine the kind of immunological regulation that must be taking place for that to work.

                                So you'd assume we have several genes highly specific to our placenta that appear when we Eutherians first appeared... right? No! Turns out the vast majority already existed in jawed vertebrates (our common ancestor with sharks), then quite a lot show up in bony fish (our common ancestor with most things you call fish), and just one shows up in Tetrapoda (our common ancestor with amphibians).

                                So most of the framework for developing an organ such as the placenta already existed for millions of years, so what exactly was missing before it could finally show up in evolutionary history? The two genes that are absolutely required for this whole crazy "let's invade the mother's uterine wall tissue but NOT trigger her immune system" part: CSF2 and a group of closely related genes called syncitins.

                                Syncitins are the star here, because they're actually a gene that came from ancient retroviruses. In the virus, they were expressed in the envelope and controlled the fusion between the viral particle and the host cell. These viruses got integrated into our genome, and this "fusion with the host cell" mechanism became extremely useful and crucial for the placenta, basically allowing it to exist.

                                J This user is from outside of this forum
                                J This user is from outside of this forum
                                [email protected]
                                wrote on last edited by
                                #29

                                Thanks for talking about that, that's really cool!

                                1 Reply Last reply
                                2
                                • gandalf_der_12te@discuss.tchncs.deG [email protected]

                                  So, in other words, viruses did parts of the work of evolution by inventing the CSF2 and syncitin genes?

                                  And that regulates the immune system to not respond to foreign tissue?

                                  K This user is from outside of this forum
                                  K This user is from outside of this forum
                                  [email protected]
                                  wrote on last edited by
                                  #30

                                  Basically, yes. Viruses came up with the syncitins to fuse with host cells, then when they infected us and integrated their genome we had the code for making these proteins... and turns out "invading tissue" was a really useful tool for the embryo.

                                  gandalf_der_12te@discuss.tchncs.deG 1 Reply Last reply
                                  0
                                  • G [email protected]

                                    Some perform tasks, but they largely just take up space, and that’s a good thing. Your body’s full of materials that malignantly pathogenic bacteria would love to get their hands on. Bacteria that are largely incapable of doing anything to us take up space that would otherwise be occupied. You’d likely prefer an old squatter living in your walls, rather than a crackhead. You’d probably choose an electrician, but that’s life. Better they’re largely benign than overtly and desperately malicious.

                                    You factually do have a viral balance in your internal ecosystem. Bacteriophages cull populations, and some viruses hyper-specialize in attacking cancer. There are more examples, but I can’t immediately recall

                                    gandalf_der_12te@discuss.tchncs.deG This user is from outside of this forum
                                    gandalf_der_12te@discuss.tchncs.deG This user is from outside of this forum
                                    [email protected]
                                    wrote on last edited by
                                    #31

                                    thank you, that makes sense to me.

                                    i'm interested in actually understanding what functions what elements of the gut microbiome perform. but i guess that's a highly complicated topic, so i expect no quick answers

                                    G 1 Reply Last reply
                                    0
                                    • K [email protected]

                                      Happily! Basically, the true placenta we mammals (Eutheria) have is what allows such a long gestation period. Unlike our closely related marsupials, that quickly deplete their resources and must give birth, our placenta allows for a continuous exchange of nutrients. This involves a quite complicated process of embryonic tissue invading the uterine wall, so you can imagine the kind of immunological regulation that must be taking place for that to work.

                                      So you'd assume we have several genes highly specific to our placenta that appear when we Eutherians first appeared... right? No! Turns out the vast majority already existed in jawed vertebrates (our common ancestor with sharks), then quite a lot show up in bony fish (our common ancestor with most things you call fish), and just one shows up in Tetrapoda (our common ancestor with amphibians).

                                      So most of the framework for developing an organ such as the placenta already existed for millions of years, so what exactly was missing before it could finally show up in evolutionary history? The two genes that are absolutely required for this whole crazy "let's invade the mother's uterine wall tissue but NOT trigger her immune system" part: CSF2 and a group of closely related genes called syncitins.

                                      Syncitins are the star here, because they're actually a gene that came from ancient retroviruses. In the virus, they were expressed in the envelope and controlled the fusion between the viral particle and the host cell. These viruses got integrated into our genome, and this "fusion with the host cell" mechanism became extremely useful and crucial for the placenta, basically allowing it to exist.

                                      7 This user is from outside of this forum
                                      7 This user is from outside of this forum
                                      [email protected]
                                      wrote on last edited by
                                      #32

                                      That is nuts and a really good explaination, thank you!

                                      1 Reply Last reply
                                      2
                                      • K [email protected]

                                        Basically, yes. Viruses came up with the syncitins to fuse with host cells, then when they infected us and integrated their genome we had the code for making these proteins... and turns out "invading tissue" was a really useful tool for the embryo.

                                        gandalf_der_12te@discuss.tchncs.deG This user is from outside of this forum
                                        gandalf_der_12te@discuss.tchncs.deG This user is from outside of this forum
                                        [email protected]
                                        wrote on last edited by
                                        #33

                                        i am wondering (in case you know), what activates these genes?

                                        i.e., i'd like to understand how gene regulation works in general. what causes genes to become active all of a sudden?

                                        i.e., why does the genes allow embryos to live inside the mother, but not allow other intruders to live inside the human?

                                        K 1 Reply Last reply
                                        1
                                        • T [email protected]

                                          Who's going to tell them about prions?

                                          A This user is from outside of this forum
                                          A This user is from outside of this forum
                                          [email protected]
                                          wrote on last edited by
                                          #34

                                          They're like an origami figure folded wrongly that causes any properly folded origami figures to become misfolded when it comes in contact with them.

                                          1 Reply Last reply
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