Universal Coronavirus Vaccine Breakthrough: A Single Shot That Could Protect You From COVID, MERS, and the Common Cold
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About a month ago I had the flu - the real flu - for the first time either in ages, or in my life, and I actually had gotten vaccinated in autumn, and man, I thought I was dying. For two weeks I couldn't do anything. Just looking at the stairs gave me endocarditis. I never run fevers and I was just popping painkillers to keep it under 40 degrees. That was nuts. So during and afterwards I mostly been thinking about three things: 1. I would have died for real if I didn't have some basic protection from the vaccine, 2. I want a vaccine against the common cold as well, and 3. Jesus Christ please I don't want to die from a stupid cold or flu, at least make it Covid, but that's such a lowball way to go
I had a similar experience, also a month ago. Lots of people I know had it similar the last few months. Is there another wave of this going around and this time I'm noticing?
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I wonder how this could help those with long COVID.
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Now consider that Scripps Research, who is developing this, is US-based and receives a lot of federal government funding, and that Trump/Musk/DOGE have been slashing and burning all kinds of federal science staffing and funding. Also consider that their main federal funding comes from HHS, which RFK Jr., notorious vaccine hater, heads.
Then weep. Progress on this may be stalled for a long time.
File --> export
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I wonder how this could help those with long COVID.
I don't think it's going to help them. long covid is past the stage of virus infection. It's where the body is attacking itself.
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I don't think it's going to help them. long covid is past the stage of virus infection. It's where the body is attacking itself.
It depends! Sometimes it's autoimmune, sometimes it's lingering virus, sometimes it's disrupted regulatory systems, etc. When it's the immune system or lingering virus, a new vaccine can often get the immune system to relearn how to correctly handle the virus
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I have absolutely no idea. I wouldn't know how to do it without a yellow card and that requires residence. Maybe there's clinics?
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I wonder how this could help those with long COVID.
Took me over half a year to get over covid.last time. I coughed so.much and so hard for so long I got a hernia.
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About a month ago I had the flu - the real flu - for the first time either in ages, or in my life, and I actually had gotten vaccinated in autumn, and man, I thought I was dying. For two weeks I couldn't do anything. Just looking at the stairs gave me endocarditis. I never run fevers and I was just popping painkillers to keep it under 40 degrees. That was nuts. So during and afterwards I mostly been thinking about three things: 1. I would have died for real if I didn't have some basic protection from the vaccine, 2. I want a vaccine against the common cold as well, and 3. Jesus Christ please I don't want to die from a stupid cold or flu, at least make it Covid, but that's such a lowball way to go
Drowning is probably the best way to go excluding the obvious opiate overdose forever sleepy time. It's not drawn out like freezing to death.
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I don't think it's going to help them. long covid is past the stage of virus infection. It's where the body is attacking itself.
Doesn't chickenpox turn into shingles by infecting the nervous system?
Could long covid be related to that?
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Three microchips at once that's awesome! /s
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After the most recent flu or cold I had. I would do anything for a cold vaccine. Flu shot likely kept me safe from that last bug I had. But still would like a cold vaccine to.
I had the cold and COVID back-to-back. I felt much worse with the cold. It turned into a chest infection that took about three weeks to get over. And then right as I got over that, I caught COVID. I was just tired with COVID. Like I had a fever and some coughing, but aside from that I was just sleepy.
Joke’s on me though; That was over a year ago, and I still have long COVID.
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No way they'll let Americans have it
We’ve got a lot of Americans who want everything tested for 20 years to make sure your eyes don’t fall out after a decade.
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Doesn't chickenpox turn into shingles by infecting the nervous system?
Could long covid be related to that?
The virus that causes chicken pox, lies dormant in your nervous system, where your immune system can’t get it, for decades. Then much later in life the virus can reactivate, infect along those nerves, causing shingles.
This is the important part of the chicken pox vaccination the we don’t talk about nearly enough.
- If you get chicken pox, you’ll probably be ok (although not everyone is) and get over it, becoming immune. But the virus will still lurk, opening you to shingles attacks when you’re much older
- if you get the vaccination, you’ll probably not only not get chicken pox, but will also not get shingles
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Drowning is probably the best way to go excluding the obvious opiate overdose forever sleepy time. It's not drawn out like freezing to death.
I don't fancy spending a few minutes trying to breathe water.
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is far to powerful to throw completely away.
They could do the same with DoE and it isn't saving that agency. There's no particular reason the FDA would fare any better. They'll strip it to the bone and some states will cheerfully make it completely legal for their citizens.
We'll see. I feel like there's more value keeping around the institution which says what substances and food you can or cannot sell and who can or cannot sell them than there is in the institution dedicated to making sure everyone has schooling, indoctrination is easier if people are stupid.
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The virus that causes chicken pox, lies dormant in your nervous system, where your immune system can’t get it, for decades. Then much later in life the virus can reactivate, infect along those nerves, causing shingles.
This is the important part of the chicken pox vaccination the we don’t talk about nearly enough.
- If you get chicken pox, you’ll probably be ok (although not everyone is) and get over it, becoming immune. But the virus will still lurk, opening you to shingles attacks when you’re much older
- if you get the vaccination, you’ll probably not only not get chicken pox, but will also not get shingles
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I wonder how this could help those with long COVID.
Many long COVID infections are causing/caused significant damage to organs (https://pmc.ncbi.nlm.nih.gov/articles/PMC11834749/). A vaccination isn't going to reverse organ damage.
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Yeah I also don't understand this part. Can the antibodies targeting the bare spike protein attach to it despite the presence of the sugars? Or are there a few spike proteins in the virus which do not have the sugars, not enough to effectively develop antibodies but enough for already existing antibodies to attach to?
I may have missed it in the article, I'm not in life sciences so I don't have all the prerequisite knowledge for this
from what ive gathered from the abstract,t he glycosolation prevents a more robust immune response, less antibody titers, when they removed it they noticed the immune system recognizes the spike proteins more easily so a stronger immune response and more antibody produced, and a longer titre of antibodies.
first when they removed the "glycans" it revealed more of the protein of the virus, so the immune system recognizes different parts or more of it, so stronger and longer last immune response. the conserved parts is the parts of the proteins that dont mutate much so its easier to become immune to it, the sugars originally hid that part.
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Finally, someone speaking actual biology instead of paranoid rants. Impressive grasp of glycosylation and conserved epitope exposure - you've clearly done your reading beyond headlines. The sugar-stripping approach is ingenious precisely because it targets what viruses try to hide. Current research trajectory looks promising but I'll wait for peer-reviewed publications after that ACS meeting before joining the hype train.
i was thinking the same about the abstract, the glycans were shielding the conserved parts epitopes that arnt prone to mutations,
