Universal Coronavirus Vaccine Breakthrough: A Single Shot That Could Protect You From COVID, MERS, and the Common Cold
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This didn't answer the question for me.
I get the 1st part: They've unhidden a stable spike protein hidden by sugars and used it to create an immune response.
The long-term effectiveness is where I'm getting lost. How will the immune system know when to use these particular anti-bodies in the future? If, say, 5 years after being vaccinated I'm infected, surely the relevant spike proteins are hidden by sugars. So how can my body recognise them as the same protein and make more of the correct anti-bodies?
As I understand it, "hidden" is a relative thing. Before exposure one's immune system doesn't know what to look for, after exposure, and immune response, one's T and B cells have a much better chance. That's why denovo immune response to an epitope may not be sufficient, but once the immune system has been 'exposed' or 'educated' the response is much more specific. There are two parts to the immune system, innate, basically structural, and adaptive (T's and B's) that can be primed with certain factors to create a very precise response. The long term nature of immune response is dependent on those cells, which come in number of different 'flavors'. Tissue Resident Macrophages hang out in the area of initial infection, waiting for "that guy" to show up again. They can sit relatively dormant for years. I don't want to mislead, our understanding of the long term memory function of the immune system isn't completely understood. And so we don't know how long a given immune response will last, at least not yet. Does that help? I'm not an immunology prof, or researcher, so I may not have been clear.
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from what ive gathered from the abstract,t he glycosolation prevents a more robust immune response, less antibody titers, when they removed it they noticed the immune system recognizes the spike proteins more easily so a stronger immune response and more antibody produced, and a longer titre of antibodies.
first when they removed the "glycans" it revealed more of the protein of the virus, so the immune system recognizes different parts or more of it, so stronger and longer last immune response. the conserved parts is the parts of the proteins that dont mutate much so its easier to become immune to it, the sugars originally hid that part.
Generally I think you've got it. One thing to add, when you say protein above it's specifically the Spike Protein.
This article goes into it on a much deeper level than I would be able to explain.
https://en.wikipedia.org/wiki/Coronavirus_spike_protein
"The function of the spike glycoprotein is to mediate viral entry into the host cell by first interacting with molecules on the exterior cell surface and then fusing the viral and cellular membranes. " Because the spike protein is needed for mediating viral entry to the cell it has to remain in a particular structure to do that job. And so major changes to it would make it work less effectively, some minor changes might not, thus is is relatively unchanging a.k.a. conserved, because if it changed on a given virus particle, that particle wouldn't function, and thus wouldn't replicate.
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Or it could be the strict formalization of psychiatric studies, combined with the more broad based diagnosis and categorization of the school aged working class.
Is autism diagnosis really that formalized?
I was tutoring psych the other day, and the book the student had still claimed that women were much less likely to be autistic. It’s fascinating how many women don’t get diagnosed well into their thirties. It makes me really wonder what is being used to diagnosis autism, and how much of it might be affected by the tester’s bias and beliefs.
(Personally, I’ve always wanted to be tested but the 12 month plus waiting list and the $5k not covered by insurance means that I’ll probably continue going through the rest of my life without any form of work accommodation…)
Is autism diagnosis really that formalized?
Certainly moreso than a generation ago.
(Personally, I’ve always wanted to be tested but the 12 month plus waiting list and the $5k not covered by insurance means that I’ll probably continue going through the rest of my life without any form of work accommodation…)
Not unusual for kids to be picked out in grade school and referred for further diagnosis. But yeah, I can definitely get not wanting to bother going out of pocket on something like that as an adult. Not unless there's a pressing need.
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Yes, but we're slowly evolving away the dumbest and most dangerous of the population.
In the past we sent them running eagerly into the meat grinder of war.
Now they're building up like cord wood, and starting to smolder.
we’re slowly evolving away the dumbest and most dangerous of the population
Do you believe that exposure to misinformation is a consequence of genetics? Like, people are just born with an ear uniquely tuned to anti-vax radio, television, and social media?
Now they’re building up like cord wood, and starting to smolder.
"RFK Jr is getting his eugenics backwards" is one hell of a take.
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Except you supercharge the mutation of the disease as well, so its a rinse and repeat cycle.
So human keeps dropping and more remote work?
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Maybe, or maybe some other country poaches them.
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we’re slowly evolving away the dumbest and most dangerous of the population
Do you believe that exposure to misinformation is a consequence of genetics? Like, people are just born with an ear uniquely tuned to anti-vax radio, television, and social media?
Now they’re building up like cord wood, and starting to smolder.
"RFK Jr is getting his eugenics backwards" is one hell of a take.
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Is autism diagnosis really that formalized?
Certainly moreso than a generation ago.
(Personally, I’ve always wanted to be tested but the 12 month plus waiting list and the $5k not covered by insurance means that I’ll probably continue going through the rest of my life without any form of work accommodation…)
Not unusual for kids to be picked out in grade school and referred for further diagnosis. But yeah, I can definitely get not wanting to bother going out of pocket on something like that as an adult. Not unless there's a pressing need.
Not unusual for kids to be picked out in grade school and referred for further diagnosis.
Primarily children of one gender presentation, to this day. Which again, makes me very curious as to the validity of the “autism” construct.
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I believe vulnerability to misinformation is an effect of genetics, and this puts pressure on those genes to go extinct as they are not suited for survival.
I believe vulnerability to misinformation is an effect of genetics
And you came to this conclusion... genetically?
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Doesn't matter, they ll die by measels before anyway
They can die from it alone in their house. Stop going to the hospitals and infecting infants and newborns that can't get it.
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As I understand it, "hidden" is a relative thing. Before exposure one's immune system doesn't know what to look for, after exposure, and immune response, one's T and B cells have a much better chance. That's why denovo immune response to an epitope may not be sufficient, but once the immune system has been 'exposed' or 'educated' the response is much more specific. There are two parts to the immune system, innate, basically structural, and adaptive (T's and B's) that can be primed with certain factors to create a very precise response. The long term nature of immune response is dependent on those cells, which come in number of different 'flavors'. Tissue Resident Macrophages hang out in the area of initial infection, waiting for "that guy" to show up again. They can sit relatively dormant for years. I don't want to mislead, our understanding of the long term memory function of the immune system isn't completely understood. And so we don't know how long a given immune response will last, at least not yet. Does that help? I'm not an immunology prof, or researcher, so I may not have been clear.
Tissue Resident Macrophages hang out in the area of initial infection, waiting for "that guy" to show up again.
This is specifically the bit I'm struggling with. How will they know it's "that guy"?
It's a bit like saying "We know this criminal uses disguises. We've given everyone copies of his mugshot, which they've used for target practice. Now if he wanders in wearing a disguise, people will recognise him."
As I understand it, "hidden" is a relative thing.
I guess this is the answer?
Going back to my analogy, you're saying his disguises are pretty simple. So he might wear glasses or a fake beard, but he isn't likely to turn up in a full clown outfit, with multi-coloured hair, make up, and a big red nose.
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Also, fuck cancer. (Cancer vaccines may be next, the end of the article.)
I see this often, but cancer isn't caused by a viral infection. Are there vaccines that exist to prevent non-viral related diseases?
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I see this often, but cancer isn't caused by a viral infection. Are there vaccines that exist to prevent non-viral related diseases?
That's not actually true. There's a bunch of viruses that can cause cancer:
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I see this often, but cancer isn't caused by a viral infection. Are there vaccines that exist to prevent non-viral related diseases?
Vaccines could theoretically be used to train the immune system to essentially attack cancer cells in much the same way we already use immunotherapy. Though as far as I understand it, we have yet to fully developed one.
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Tissue Resident Macrophages hang out in the area of initial infection, waiting for "that guy" to show up again.
This is specifically the bit I'm struggling with. How will they know it's "that guy"?
It's a bit like saying "We know this criminal uses disguises. We've given everyone copies of his mugshot, which they've used for target practice. Now if he wanders in wearing a disguise, people will recognise him."
As I understand it, "hidden" is a relative thing.
I guess this is the answer?
Going back to my analogy, you're saying his disguises are pretty simple. So he might wear glasses or a fake beard, but he isn't likely to turn up in a full clown outfit, with multi-coloured hair, make up, and a big red nose.
I like your examples, and they might be close enough metaphorically. To stretch your metaphor to the breaking point, if the camo is so big it interferes with function, like the clown outfit, then the virus is "dead in the water", and can't replicate. If it's just a different hat or glasses, and doesn't interfere with function, then replication can happen.
I'm also waiting for that virologist or immunologist who is gonna correct the bits where I'm missing the point. I know some of those folks are out here 'on fedi', lol, but they might be disguised.
It looks like there's some discussion going on over on Bluesky about this presentation at ACS Spring 2025, which found using Universal Coronavirus Vaccine search string. Denis - The COVID Info Guy seemed particularly informative.
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That's not actually true. There's a bunch of viruses that can cause cancer:
So we'd be vaccinating those infections, not cancer itself
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I see this often, but cancer isn't caused by a viral infection. Are there vaccines that exist to prevent non-viral related diseases?
Some of them can be. HPV is the typical cause of cervical cancer, which is the one I can think of off the top of my head.
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Vaccines could theoretically be used to train the immune system to essentially attack cancer cells in much the same way we already use immunotherapy. Though as far as I understand it, we have yet to fully developed one.
I'm a bit concerned about that TBH. I'm not a doctor or medical researcher though so if they make one I'll probably be an early adopter anyway. But since cancer cells are body cells with a problem, it feels like a screw up on a cancer vaccine would just lead to some exciting new autoimmune disease.
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Tha's a new thing for me.
I wish they had detailed how the removal of glycans is accomplished. Alas, Wikipedia doesn't even have an article about "glycoengieering", which would likely be the term for this method.
