Everybody else will act normal and all prior evidence of their existence will also persist like normal.

I guess for most people it would be pretty much immediately if their significant other isn't there in the morning and for some fringe isolated cases it might take forever.

I guess best case for me would be around 4 hours on a work day during lunch break seeing a big crowd of people when it would finally click.

Worst case would be probably 5 days when I'm mostly working from home office.

Immediately, but mostly because theres only women in the office i work on.

Monday, it would be too much of a coincidence to see a lot of my coworkers missing at the same time, and seeing people talk to nobody beside them would make me think I'm going crazy.

On the weekend I'm not forced to interact with anyone so I could feasibly go without noticing.

Where TF did my family go?

Would notice immediately when I go to work, too much of a strange coincidence for most of my office to be missing.

Plus I guess you're saying they still exist? So it would be sort of like being in an office full of ghosts still going about their day, I'd keep seeing invisible people answering calls, printing stuff to the printer, etc.

Immediately. My only close friends at this point in my life are women

No I mean everybody is essentially hypnotized to not notice them missing except you. Even if you were to ask somebody "How's your wife/husband?" They would answer you "She's/He's fine."

Depends. Does the hypnotism make them think a patient has arrived? Will parents bring in children who don't exist?

If it does, then super quickly. If it doesn't, then a while.

Only the boss isn't the same gender as the rest of the team and today is their RDO.

Instantly? Where the fuck is my husband. If only I can't see him but my twin can I guess me, my now invisible to me husband, and I go to the hospital to ask "yo something is very weird in her brain"

Edit - oh they'd think it's normal they're gone.

I guess argue with my twin for hours about my husband still should exist and not have disappeared.

Not for at least 3 days when I do my shopping inbetween my NEET life

Well, we're planning to watch the super bowl in an hour and half. It would be pretty noticeable if all men were gone.

I would notice pretty quick when I'm not being catcalled on my way to work

What happens to intersex people?

They turn into the failed Ripley clones from Alien Resurrection.

Intersex people don't vanish.
If you yourself are intersex, nobody vanishes for you.
Trans People vanish based on their passability for the opposite sex, if they're androgynous they don't vanish.
If you yourself are trans then the opposite of your prefered gender vanishes.

Ah Shit I'm. Non-binary and opposite sex doesn't exist, so I'm opposite of non-binary? Binary? That's still not accurate, wait isn't saying opposite sexism just non binary erasure, so like, I don't fucking know??!? But like sex and gender are social constructs so like, maybe some people will. Just poof but idk. Who would it be, if someone changes sex or there gender do they just poof? Like this whole question is fucking weird???!?

Check one of my other answers to the comments.

Yeah this seems to be a question for mainly people living alone... I'd notice within the hour.

But like sex and gender are social constructs

Honest response here, no hate intended: I thought gender was a social construct but sex is biological?

Ditto. I'd have so few friends, not to mention my wife and daughter (no males in the house other than me) so things would be pretty confusingly lonely, pretty quick!

At least OP was pretty clear that all people of the opposite sex were to have disappeared so I can still have my dog.